When you are using the default OWA configuration you have to specify the "exchange" virtual directory in order to check your email. The URL looks like this: "https://mail.mydomain.com/exchange".
The following screencast demonstrates how to use the main URL: "https://mail.mydomain.com" by configuring a redirection to a URL.
How to Install Exchange Server 2010 on Windows Server 2008 R2
Exchange Server 2010 Initial Configuration
How to enable Anti-Spam Features on Exchange 2010 Hub Transport Server
Upgrading Active Directory Domain to Windows Server 2008 AD DS Domain
How to Install Exchange 2007 Edge Transport Server on Windows 2008
How to Configure Server Backup in SBS 2008. Getting Started Tasks.
How to Add a Disclaimer in Exchange Server 2007
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